葡萄糖代谢和糖尿病与心率变化的关联:基于人口的队列研究
Linling Yu1,2, Meng Yang3, Xiuquan Nie1,2
1Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
禁食血葡萄糖和糖尿病的升高可能导致心率变化率 (HRV) 降低. 这项纵向研究发现,较高的葡萄糖水平和糖尿病在HRV下降之前发生,而不是相反.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 自主神经系统功能 自主神经系统功能
背景情况:
- 心率变化 (HRV) 反映了自主神经系统的功能.
- 葡萄糖代谢和糖尿病与心血管疾病有关.
- 葡萄糖代谢,糖尿病和HRV之间的时间关系需要阐明.
研究的目的:
- 研究葡萄糖代谢,糖尿病和HRV之间的因果关系和时间关系.
- 为了确定葡萄糖代谢或糖尿病是否会随着时间的推移而导致HRV变化.
主要方法:
- 一项对3858名中国成年人的队列研究,基线和6年随访.
- 测量包括HRV指数 (LF,HF,TP,SDNN,r-MSSD) 和葡萄糖平衡标志物 (FPG,FPI,HOMA-IR).
- 交叉滞后面板分析被用来评估时间关系.
主要成果:
- 禁食血葡萄糖 (FPG),胰岛素 (FPI),HOMA-IR和糖尿病在截面上与HRV指数负相关.
- 从基线FPG到随访SDNN和从基线糖尿病到减少HRV组 (TP,SDNN,r-MSSD) 观察到显著的单向路径.
- 从基线HRV到随访葡萄糖代谢或糖尿病没有发现任何显著的途径.
结论:
- 升高的FPG和糖尿病的存在似乎是随着时间的推移减少HRV的因果因素.
- 这些发现表明,葡萄糖代谢受损可能是自主功能障碍的前身,并有助于自主功能障碍.
- 针对血糖控制的干预措施可能有利于HRV.
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