德拉诺利德和阿尔特米西宁对改善实验性自身免疫脑膜炎的影响,通过调节炎症和转蛋白化
Niloufar Salehi1, Mitra Nourbakhsh2,3, Shokoofe Noori4
1Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Molecular neurobiology
|June 30, 2023
概括
德诺利德 (TEH) 和阿尔特米西宁 (ART) 在治疗多发性硬化症 (MS) 的模型实验性自身免疫脑膜炎 (EAE) 中表现有前途. TEH在减少炎症和促进髓化方面比ART更有效,这表明MS治疗的潜力.
科学领域:
- 神经免疫学 神经免疫学
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 多发性硬化症 (MS) 是一种中枢神经系统自身免疫性疾病.
- 艺术素 (ART) 在实验性自身免疫脑膜炎 (EAE) 中具有抗炎作用,这是一种MS模型.
- 德诺利德 (TEH) 是一种新型化合物,其结构与ART相似.
研究的目的:
- 研究TEH对EAE发展的改善作用.
- 在EAE小鼠模型中比较TEH与ART的疗效.
- 在EAE中识别TEH和ART的分子标.
主要方法:
- 在使用MOG35-55.5的雌性C57BL/6小鼠中诱导EAE.
- 小鼠接受了TEH (0.28毫克/公斤/天) 或ART (2.8毫克/公斤/天) 的治疗,持续了18天.
- 分析了脊髓中的临床分数,细胞因子水平 (ELISA) 和基因表达 (qRT-PCR).
主要成果:
- 无论是TEH还是ART都显著缓解了EAE的临床症状.
- TEH比ART更有效地降低了IL-6和IL-17的分泌和基因表达.
- 参与T细胞分化 (FOXP3,GATA3,T-bet) 和髓化 (MBP,AXL) 的TEH和ART调节基因.
结论:
- TEH和ART有效调节EAE中的炎症和髓化基因.
- 在改善EAE方面,TEH表现出比ART更大的功效.
- TEH要求进一步调查多发性硬化症管理中的潜在治疗应用.
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