妊娠中状细胞危机:对胎儿和新生儿的影响
Ashley Appiagyei Cole1,2, Stephen M Wagner1,2, Megha Gupta1,2
1Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA.
NeoReviews
|June 30, 2023
概括
状细胞病 (SCD) 导致红细胞状,阻断血液流动并损害器官. 患有SCD的孕妇面临更高的母亲和婴儿并发症的风险.
科学领域:
- 血液学 血液学 血液学
- 遗传学 遗传学是一种遗传学.
- 生殖医学 生殖医学
背景情况:
- 状细胞病 (SCD) 是全球普遍存在的一种遗传性血液疾病.
- 它不成比例地影响非洲血统的个人,每年在美国影响10万名出生.
- SCD涉及异常的血红蛋白,导致在脱氧化过程中形成状的红细胞.
研究的目的:
- 审查状细胞疾病的病理生理学.
- 为了突出与SCD患者怀孕相关的风险增加.
- 强调对母亲,胎儿和新生儿健康结果的影响.
主要方法:
- 关于SCD病理生理学的文献综述.
- 对SCD患病率的流行病学数据的分析.
- 在孕妇SCD患者的临床结果的综合.
主要成果:
- 在SCD中脱氧的红细胞形成了形状.
- 这种形导致血管封闭,导致缺血和器官损伤.
- 怀孕加剧了风险,增加了血管封闭性危机和不利的母胎后果.
结论:
- 由于血管封闭和器官功能障碍,SCD带来了重大的健康挑战.
- 在SCD患者的怀孕需要加强医疗监测.
- 有效的管理对于减轻孕产妇和新生儿发病率和死亡率的风险至关重要.
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