与COVID-19幸存者的肺功能异常相关的炎症
Roberto Mancilla-Ceballos1, Kathryn M Milne2,3, Jordan A Guenette3,4
1Internal Medicine Department, Hospital Regional de Alta Especialidad de La Peninsula de Yucatan, Yucatan, Mexico.
BMC pulmonary medicine
|June 30, 2023
概括
炎症生物标志物的增加,包括中性粒细胞与淋巴细胞比率 (NLR),与严重的COVID-19幸存者的持续性肺功能异常有关. 这些发现强调了炎症在感染后的长期肺部继发症中的作用.
科学领域:
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 众所周知,COVID-19会激活炎症通路,可能导致器官功能障碍.
- 在COVID-19幸存者中报告了肺功能异常,但潜在的生物机制尚未完全理解.
研究的目的:
- 为了研究血清炎症生物标志物和肺功能之间的关联,在从严重的COVID-19中恢复过来的个人中.
主要方法:
- 对从严重的COVID-19中康复的患者的前性评估.
- 血清生物标志物在住院期间 (入院,高峰期,出院) 被测量.
- 肺功能测试是在出院后大约六周进行的.
主要成果:
- 具有限制性螺旋计的患者显示了较高的中性粒细胞与淋巴细胞比率 (NLR) 和C-反应蛋白水平的峰值.
- 异常扩散能力与基线升高和NLR峰值以及Troponin-T峰值相关.
- 多变量分析表明,生物标志物仅解释了肺功能结果差异的一小部分.
结论:
- 炎症生物标志物水平的增加与COVID-19幸存者的肺功能受损有关.
- 炎症在COVID-19后肺部并发症的发展中起着重要作用.
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