慢性子宫内膜炎和治疗对无法解释的不孕症患者的影响
Juan Gu1, Qingqing Sun2, Yujuan Qi1
1Reproductive Medical Center of Xuzhou Central Hospital, 221000, Xuzhou, China.
BMC women's health
|June 30, 2023
概括
慢性子宫内膜炎 (CE) 在无法解释的不孕症中很常见. 用抗生素诊断和治疗CE显著改善了怀孕和活产率,同时降低了受影响妇女流产率.
科学领域:
- 生殖医学 生殖医学
- 妇科 妇科医生 妇科
- 不孕症研究 不孕症研究
背景情况:
- 无法解释的不孕症影响了大量寻求生育治疗的夫妇.
- 慢性子宫内膜炎 (CE) 是一种新兴的因素,与植入失败和重复的妊娠流产有关.
- 准确的诊断和有效的CE治疗对于改善生殖结果至关重要.
研究的目的:
- 调查慢性子宫内膜炎 (CE) 患病率的原因不明的不孕症患者.
- 评估CE对临床妊娠结果的影响.
- 评估抗生素治疗CE在提高生育率方面的疗效.
主要方法:
- 分析了145名患有不明原因不孕症的患者和42名对照患者的队列.
- 透镜和免疫组织化学测试 (CD38,CD138) 用于诊断CE.
- 被诊断为CE的患者接受了为期14天的口服抗生素治疗.
- 临床怀孕率,自发流产率和携带婴儿的家庭率在各组之间进行了比较.
主要成果:
- 原因不明的不孕症中CE的患病率为51.7%,明显高于对照组 (28.6%).
- 与未接受治疗的患者相比,接受治疗的CE患者的临床怀孕率 (61.3%) 和携带婴儿回家率 (60%) 较高 (43.1%和36.2%).
- 在接受治疗的CE患者中,自发流产率明显低 (2.2%),低于未接受治疗的患者 (16.0%).
结论:
- 建议对CD38和CD138进行免疫组织化学的透镜检查,以及时诊断无法解释的不孕症的CE.
- 对CE的抗生素治疗显著改善了临床妊娠结果,包括更高的活产率和更低的流产率.
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