弗洛芬尼科尔持续释放颗粒:在猪身上进行的体外与体内相关性研究
Wei-Cong Yang1, Zi-Yao Liu1, Yun-Xiao Zhang1
1Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou, 510642, China.
BMC veterinary research
|June 30, 2023
概括
佛罗芬尼科尔持续释放颗粒 (FSRGs) 开发并测试了药物释放. 确立了强烈的体外-体内相关性,允许预测FSRG性能.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 兽医药理学 兽医药理学
背景情况:
- 佛罗芬尼科尔是兽医中必不可少的抗生素.
- 开发持续释放配方可以提高药物的疗效,并减少药物的使用频率.
- 鉴定佛洛芬尼科尔持续释放颗粒 (FSRG) 的特征对于优化其治疗用途至关重要.
研究的目的:
- 为了合成和描述florfenicol持续释放颗粒 (FSRGs) 的制药特性.
- 在不同的pH条件下评估FSRGs的体外药物释放概况.
- 为了确定猪体内FSRG的体外-体内相关性 (IVIVC).
主要方法:
- 使用单酸盐,聚乙烯甘醇4000和粉合成FSRGs.
- 实验室溶解研究使用旋转篮子方法在pH 1.2 HCl和pH 4.3 酸盐缓冲中进行.
- 在猪身上进行的一项药理动力学研究涉及静脉注射弗洛芬尼科尔溶液和口服剂量FSRGs在禁食和食状态.
主要成果:
- 希古奇模型最好地描述了两种pH介质中的药物释放动力学,表明扩散和溶解是释放机制.
- 对于FSRGs,成功地确定了A级的体外-体内相关性.
- 从体外溶解数据可以可靠地预测FSRGs的体内药物释放特征.
结论:
- 开发的FSRG证明了可预测的药物释放动力学.
- 已建立的A级IVIVC验证了用于预测FSRGs体内性能的体外溶解方法.
- 这些发现支持FSRG在兽医应用中改善花尼科尔输送的潜力.
相关概念视频
01:16Methods for Studying Drug Absorption: In vitro
261
In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
261
01:09Methods for Studying Drug Absorption: In situ
272
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
272