癌症中m6A调节蛋白的表观遗传修饰
Yumin Wang1, Yan Wang2, Harsh Patel3
1Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, 100049, China.
Molecular cancer
|June 30, 2023
概括
通过特定蛋白质调节的N6-甲基氨酸 (m6A) 修饰在癌症中至关重要. 本综述探讨了表观遗传变化如何影响这些m6A调节器,影响癌症的发展和进展.
科学领域:
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 在瘤学瘤学.
背景情况:
- N6-甲基氨酸 (m6A) 修改是通过特定调节器调节的动态RNA变化.
- 异常的m6A修饰和调节器与癌症的各个方面有关,包括发生,发展,进展和预后.
- 癌症中m6A调节者的确切作用和机制尚未完全理解.
研究的目的:
- 总结目前对m6A调节器在癌症中的作用的理解.
- 阐明表观遗传修饰在癌症发生过程中影响m6A调节者的机制.
- 增强对控制瘤发生过程中的m6A调节者的表观遗传调节网络的理解.
主要方法:
- 关于m6A调节器及其在癌症中的功能研究的文献综述.
- 通过各种表观遗传修饰来调节m6A调节者的新兴研究分析.
- 影响癌症m6A调节者的表观遗传修饰作用和机制的分离.
主要成果:
- m6A调节剂在不同类型的癌症中充当瘤抑制剂或瘤基因.
- 表观遗传修饰,如无处不在,SUMOylation,乙化,甲基化,化,O-GlcNAcylation,ISGylation和乳酸化可以调节m6A调节器.
- 非编码RNAs也在癌症的背景下对m6A调节者的调节中发挥作用.
结论:
- 了解表观遗传修饰和m6A调节器之间的相互作用对于破译它们在癌症中的作用至关重要.
- 本综述巩固了当前的知识,强调了表观遗传调节在m6A介导癌症发展中的重要性.
- 对这些表观遗传调节机制的进一步研究将改善我们对癌症生物学的理解,并可能揭示新的治疗点.
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