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中国与酒精有关的肝病的流行病学特征:系统性审查和元分析
Zongzhe Tang1, Yajie Ding1, Wei Zhang2
1Department of Fundamental and Community Nursing, School of Nursing, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, Jiangsu, China.
BMC public health
|June 30, 2023
概括
在中国,与酒精有关的肝病 (ALD) 的患病率正在增加,特别是在男性和长期饮酒者中. 公共卫生策略对于解决这些ALD上升趋势至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 与酒精有关的肝病 (ALD) 在全球范围内构成了重大公共卫生挑战.
- 了解中国ALD的流行病学特征对于有针对性的干预至关重要.
研究的目的:
- 对中国与酒精有关的肝病 (ALD) 的流行病学特征进行元分析.
- 为了确定ALD在中国不同的人口和时间段的综合流行率.
主要方法:
- 对2000年1月至2023年1月期间发表的研究进行了对6个数据库 (3个英语,3个中文) 的系统文献搜索.
- 使用DerSimonian-Laird随机效应模型来计算聚合流行率的元分析.
- 包括21项研究来分析基于性别,地区,饮酒持续时间和时间间隔的ALD患病率.
主要成果:
- 在中国,ALD的整体综合患病率为4.8%.
- 患病率在男性 (9.3%) 与女性 (2.0%) 相比较高,并且在区域上有所不同,中国西部患病率最高 (5.0%).
- 随着酒精饮用史的延长,ALD的患病率增加 (0.9%为<5年至9.9%为>10年),并且从2005-2010年 (4.3%) 到2011-2016年 (6.7%) 呈现上升趋势.
结论:
- 近几十年来,中国与酒精有关的肝病的患病率一直在上升.
- 在不同的人口亚组中,ALD患病率存在显著差异.
- 需要有针对性的公共卫生战略,重点关注高风险人群,例如长期饮酒的男性.
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