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岛屿移植:克服器官短缺问题

Marluce da Cunha Mantovani^1,2, Ilana Gabanyi¹, Carlos Andrés Pantanali³

¹Cell and Molecular Therapy NUCEL Group, School of Medicine, University of São Paulo, Avenida Dr. Arnaldo, 455, São Paulo, 01246-903, SP, Brasil.

Diabetology & metabolic syndrome

|June 30, 2023

概括

胰腺移植岛屿的报价经常因高血糖症,技术问题,年龄,血清学和高amylasemia而被拒绝. 解决这些因素可以提高1型糖尿病治疗器官接受率.

科学领域:

移植免疫学移植免疫学
内分泌学在内分泌学.
器官捐赠和采购器官的捐赠和采购

背景情况:

1型糖尿病 (T1D) 是由胰腺β细胞的自身免疫破坏引起的,需要终身胰岛素治疗,并且往往无法预防并发症.
胰腺小岛移植为T1D提供了一个有希望的替代方案,但由于缺乏合适的捐赠胰腺而受到限制.

研究的目的:

分析胰腺拒绝岛屿隔离和移植的原因.
确定改善器官接受率的策略.

主要方法:

对2007年1月至2010年1月期间提供的大脑死亡的人类胰腺捐赠者的回顾性研究.
评估捐赠者的个人资料和器官拒绝的原因.

主要成果:

在558个胰腺供应中,512个 (88.2%) 被拒绝,46个 (11.8%) 被接受岛屿隔离.
拒绝的主要原因包括高血糖症,技术问题,捐赠者的年龄,阳性血清学和超胺血症.

结论:

了解巴西圣保罗胰腺供应下降的主要原因至关重要.
实施有针对性的干预措施可以提高胰腺捐献者的资格,改善岛屿隔离和移植结果.

关键词:

糖尿病是一种糖尿病.岛屿移植移植的方法器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐赠器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器胰腺是什么? 胰腺是什么?胰腺捐赠者的个人资料和选择

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