血清DHEA和水平与老年男性的冠状动脉化相反相关
Claes Ohlsson1,2, Maria Nethander1,3, Anna-Karin Norlén4
1Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden.
血清脱水氨 (DHEA) 和水平与老年男性的冠状动脉下部化 (CAC) 有关. 这些发现表明,上腺和丸中的雄激素可能支持心血管健康.
科学领域:
- 内分泌学 在内分泌学.
- 心血管科学 心血管科学
- 老年学是一门学科.
背景情况:
- 众所周知,性类固醇对男性有心血管影响,但潜在的机制尚未完全理解.
- 血管化是一种受调节的过程,对心血管事件具有潜在的病理生理学意义.
研究的目的:
- 调查血清性类固醇水平与老年男性冠状动脉化 (CAC) 之间的关联.
主要方法:
- 在1287名老年男性中,使用气体染色学双重质谱分析了一份全面的性别类固醇档案.
- 测量了脱氨 (DHEA),氨,,二,雌激素和雌激素的血清水平.
- 冠状动脉化 (CAC) 通过计算机断层扫描来确定.
主要成果:
- 血清中DHEA,androstenedione,,dihydrotestosterone和生物可用的的水平与CAC相反地相关.
- 在调整心血管风险因素后,DHEA,和生物可用的仍然与CAC相关.
- 在上腺衍生DHEA和丸衍生丸与CAC之间观察到部分独立的关联.
结论:
- 血清DHEA和水平与老年男性的CAC相反相关,彼此独立.
- 来自上腺和丸的雄激素可能有助于男性心血管健康.
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