眼睛参与输血依赖的沙拉西米亚儿童儿童
M J Uddin1, M I Hossain, S F Sonia
1Dr Mohammed Jamal Uddin, Assistant Professor, Department of Pediatrics, Jahurul Islam Medical College Hospital, Kishoreganj, Bangladesh;
Mymensingh medical journal : MMJ
|July 1, 2023
概括
血病患者输血后的铁过量会导致眼睛问题. 这项研究发现,较高的铁含量和较长的疾病持续时间显著增加了视力并发症的风险,在儿童输血依赖的血病.
科学领域:
- 眼科医生 眼科 眼科
- 血液学 血液学 血液学
- 儿科 儿科 儿科
背景情况:
- thalassemia是一种常见的遗传性血液疾病,需要定期输血.
- 重复输血导致铁过载,这是一个系统性并发症,影响多个器官,包括眼睛.
- 输血依赖性沙拉西米亚 (TDT) 患者的眼部并发症是一个重大问题.
研究的目的:
- 调查患有输血依赖性沙拉西米亚的儿童眼部干扰的患病率和类型.
- 评估这些儿童眼部表现和疾病持续时间以及血清费里水平之间的关系.
主要方法:
- 一项涉及46名患有TDT的儿童 (3-18岁) 的横截面观察研究.
- 进行了全面的眼科检查,包括视敏度,裂纹灯生物显微镜和眼底镜.
- 统计分析使用学生的t测试和奇方测试 (p<0.05被认为是显著的).
主要成果:
- 在41.3%的研究儿童中检测到眼部透.
- 常见的症状包括视力敏度下降 (36.95%),角膜干燥 (15.21%),透镜不透明 (13.04%) 和光盘缩 (15.21%).
- 较高的血清费里水平和较长的疾病持续时间与眼部参与有显著的正相关性 (p<0.001).
结论:
- 儿童的输血依赖性沙拉西米亚与眼部并发症的高患病率有关.
- 血清费里水平和疾病持续时间是发展这些眼睛问题的关键风险因素.
- 定期的眼科查对于早期检测和对TDT儿童眼部变化的管理至关重要.
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