利用安慰剂:从迷幻科学中吸取的教训
Chloé Pronovost-Morgan1,2, Ido Hartogsohn3, Johannes G Ramaekers2
1Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK.
Journal of psychopharmacology (Oxford, England)
|July 1, 2023
概括
随机对照试验 (RCT) 忽略了安慰剂效应. 这项研究提出了一个新的框架,灵感来自迷幻科学,以整合非药物因素,以改善患者护理.
科学领域:
- 药理学 药理学 是一个学科.
- 精神病学是一个精神病学.
- 医学伦理 医学伦理
背景情况:
- 随机对照试验 (RCT) 隔离了药物效应,但掩盖了非药物变量的重大影响,称为安慰剂效应.
- 经验证据表明,个人和环境依赖的因素 (身体,社会,文化) 与药物有效性相互作用并影响药物的有效性.
- 在临床实践中利用安慰剂效应面临着概念和伦理方面的挑战.
研究的目的:
- 为了解和整合非药物变量在医疗实践中提出一个新的框架.
- 解决传统研究设计在考虑治疗影响的全谱方面的局限性.
- 为了在道德上利用安慰剂效应改善患者的治疗结果.
主要方法:
- 这项研究提出了一个新的概念框架,灵感来源于迷幻科学中的"设置和设置"概念.
- 该框架强调了药理和非药理因素之间的互动和协同关系.
- 它提出了用于将非药物变量重新整合到临床环境中的实际方法.
主要成果:
- 拟议的框架强调,药物和非药物变量不仅仅是附加的,而是以协同作用相互作用的.
- 它为了解背景和个体因素如何调节治疗结果提供了基础.
- 这种方法为在医学中更有效地利用安慰剂效应提供了一条途径.
结论:
- 传统的RCT设计限制了对治疗结果的非药理学影响的评估.
- 一个新的框架,通过"设置和设置"模型整合非药物变量,可以增强治疗潜力.
- 将安慰剂效应的伦理整合到生物医学工具箱中可以改善临床护理和患者利益.
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