在慢性鼻炎中,炎症溶解和专门的亲溶解脂质介质在慢性鼻炎中起作用
Peyton Z Robinson1, Daniel N Frank2, Vijay R Ramakrishnan3
1Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Expert review of clinical immunology
|July 1, 2023
概括
专门的亲解决媒介 (SPM) 通常可以解决炎症,但在慢性鼻炎 (CRS) 中会受到干扰. 研究探讨了SPM如何通过恢复这些通路来治疗CRS.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 炎症研究 炎症研究
背景情况:
- 慢性鼻炎 (CRS) 涉及复杂的炎症与细胞,分子和微生物的变化.
- 内生特种亲溶解媒介 (SPM) 通常可以解决炎症并支持抗菌防御.
- 这些关键的SPM通路在CRS患者中被破坏.
研究的目的:
- 描述慢性炎症中的CRS特征.
- 探索SPM在积极解决组织炎症中的机制.
- 调查SPM在CRS中的治疗潜力.
主要方法:
- 对CRS病理生理学当前文献的综述.
- 对动物模型和体外人类细胞培养研究的分析.
- 对人类饮食研究的审查,重点关注脂质媒介生物可用性.
主要成果:
- SPM酶途径的失调与CRS表型和微生物模式有关.
- 细胞信号传导和脂质媒介生物可用性显示出相关的变化.
- 有证据表明,在CRS中,SPM通路受到损害.
结论:
- 炎症解消的适当调节对于CRS的愈合至关重要.
- SPM失调是CRS的一个关键特征.
- 针对SPM途径可能为CRS提供一种新的治疗策略.
更多相关视频
相关概念视频
Drugs Used in Lower Respiratory Disorders: Overview
500
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
500
Inflammatory Response
2.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.2K
Drugs Used in Upper Respiratory Disorders: Overview
293
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
293
Chronic Pharyngitis
3.0K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
3.0K
Antiasthma Drugs: Leukotriene Modifiers
369
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
369
Asthma: Pathogenesis and Management
452
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
452


