全球诊断网络在五大洲的脂质分布
Seth S Martin1, Justin K Niles2, Harvey W Kaufman2
1Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 600 N. Wolfe St, Carnegie 591, Baltimore, MD 21287, USA.
European heart journal
|July 1, 2023
概括
全球脂质概况显示出国际上显著的差异,突出了一个普遍的问题,即高胆固醇水平影响全球心血管疾病风险. 了解这些差异是针对性干预的关键.
科学领域:
- 心血管疾病流行病学
- 临床化学 临床化学
- 全球健康 全球健康
背景情况:
- 脂质在心血管疾病的发展中起着至关重要的作用.
- 了解脂质配置文件的全球变化对于评估心血管风险和开发有效干预措施至关重要.
研究的目的:
- 描述不同国家的脂质谱的变化.
- 提高对心血管风险的理解,并确定降低风险干预的机会.
主要方法:
- 分析了461,888,753名年龄在20-89岁的患者的聚合脂质结果,在2018-2020年间进行了测试.
- 来自五大洲17个国家的9个实验室组织的脂质分布的评估.
- 评估平均脂质水平,世界卫生组织总胆固醇风险目标和低密度脂蛋白胆固醇 (LDL-C) 分类.
主要成果:
- 根据国家,地区,性别和年龄观察到脂质谱的显著变化.
- 总胆固醇和LDL-C水平在中年达到峰值,性别之间存在差异.
- 平均总胆固醇在几个欧洲国家和奥地利超过了世卫组织的目标,而北马其顿显示高的LDL-C,加拿大/英国显示低的LDL-C.
结论:
- 近50亿个脂质结果显示了全球的变异性,可能是由于遗传学,测试实践,生活方式和治疗.
- 升高的动脉动脉脂水平代表了全球共同的健康挑战.
- 这些发现可以为国家政策和卫生系统战略提供信息,以减轻脂质介导心血管疾病风险.
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