用于客观评估症状性脉的分子生物标志物:系统性审查和元分析
Riham N Karrar1, Siobhan Cushley2, Henry F Duncan3
1Faculty of Dentistry, University of Khartoum, Khartoum, Sudan.
International endodontic journal
|July 1, 2023
概括
像IL-8和IL-6这样的炎症生物标志物显示出诊断 Pulpitis 与自发疼痛的潜力,但需要更多高质量的研究来确认它们的准确性和预测治疗结果.
科学领域:
- 在内牙科的生物分子诊断.
- 调查脉活力的炎症标志物.
- 牙纸的健康和疾病研究.
背景情况:
- 炎症生物标志物被探索为纸状态和重要纸治疗 (VPT) 结果的诊断工具.
- 这些生物标志物的诊断准确性仍然在很大程度上是未知的.
- 为了评估它们的有效性,进行了系统审查和元分析.
研究的目的:
- 评估被调查的皮生物标志物的灵敏度,特异性和诊断几率比 (DOR).
- 为了确定生物标志物水平是否可以根据自发疼痛来区分脉的诊断.
- 评估生物标志物水平对VPT结果的预测能力.
主要方法:
- 在多个数据库 (PubMed,Scopus,Web of Science等) 中进行全面的文献搜索. 在2023年5月之前.
- 包括前性/后性观察性研究和随机试验,涉及具有重要永久牙的人类参与者.
- 不包括落叶牙,体外和动物研究;使用已建立的检查清单和指南评估偏差风险和证据质量.
主要成果:
- 56项研究分析了70多个生物分子;大多数研究质量低至相当.
- 介质素-8 (IL-8) 和介质素-6 (IL-6) 显示出诊断准确性,可以从自发疼痛的肉质中区分健康的肉质 (低确定性证据).
- 没有生物标志物显示出高DOR用于区分脉状态;有限的数据表明MMP-9与较差的全脉切除结果相关.
结论:
- 目前的炎症生物标志物缺乏准确性,无法可靠地区分脉炎的严重程度或预测关键脉治疗的成功.
- 建议提高研究质量,并研究与愈合相关的新分子.
- 标准化诊断和预后生物标志物研究对于准确评估脉炎症至关重要.
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