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阴道乳酸菌可以帮助减少尿路感染吗?
Poone S Shoureshi1, Clarissa Niino2, Karyn S Eilber3
1Department of Urology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. poone.shoureshi@cshs.org.
International urogynecology journal
|July 1, 2023
概括
阴道益生菌对预防复发性尿路感染 (rUTIs) 有希望,但需要更多的研究. 乳酸菌似乎是安全的,尽管缺乏减少RUTI的确证据.
科学领域:
- 妇科 妇科 妇科 妇科
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物学 微生物学
背景情况:
- 经常性泌尿道感染 (rUTIs) 对健康和经济造成重大负担.
- 阴道益生菌越来越多地被探索为预防RUTI的非抗生素方法.
- 现有研究强调需要对益生菌疗效进行系统审查.
研究的目的:
- 系统地审查关于阴道益生菌在预防复发性尿路感染 (rUTIs) 的有效性的证据.
- 评估乳酸菌种在阴道体形式的安全性和有效性,用于rUTI预防.
主要方法:
- 在PubMed/MEDLINE从开始到2022年8月进行了全面的文献搜索.
- 包括的研究集中在潜在的,在体内使用阴道支 suppositories 预防rUTI.
- 总共有771篇文章被选,其中8篇符合审查的纳入标准.
主要成果:
- 在评估RUTI减少的7项研究中,5项发现阴道益生菌使用的发病率下降.
- 只有两项研究,两者都涉及Lactobacillus crispatus,显示了具有统计学意义的结果.
- 三项研究证实了Lactobacillus阴道假药的有效性和安全性.
结论:
- 目前的证据表明Lactobacillus阴道假药是安全的,并为RUTI管理提供一种非抗生素的选择.
- 在使用阴道益生菌的敏感女性中,RUTI的确切减少仍然没有确定性.
- 阴道益生菌治疗的最佳剂量和持续时间需要进一步调查.
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