与IgG4相关的疾病的临床特征和复发风险因素:单中心回顾性研究
Xinhe Zhang1, Zilu Zeng1, Haoyu Tian2
1Gastroenterology Department, The First Affiliated Hospital of China Medical University, No.155 North Nanjing Street, Heping District, Shenyang, 110001, Liaoning, China.
Clinical and experimental medicine
|July 1, 2023
概括
这项关于免疫球蛋白 (Ig) G4相关疾病 (IgG4-RD) 的研究发现,年轻的年龄,低C4,多个器官参与和淋巴结参与是复发的风险因素. 临床特征因年龄和性别而异.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 免疫球蛋白 (Ig) G4相关疾病 (IgG4-RD) 是一种多系统性纤维炎症疾病.
- 了解其人口和临床特征对于有效管理至关重要.
研究的目的:
- 描述IgG4-RD患者的人口统计和临床特征.
- 为了比较不同治疗方式的疗效.
- 为了确定治疗不响应和复发的风险因素.
主要方法:
- 201名IgG4-RD患者的回顾性研究 (2016年1月 - 2020年12月).
- 收集的数据包括人口统计,临床表现,器官参与和血清IgG4水平.
- 患者接受了葡萄糖皮质激素 (GC) 单一治疗或GC + 免疫抑制剂联合治疗.
- 对反应,复发和副作用进行了12个月的监测.
主要成果:
- IgG4-RD主要影响50-70岁的个体,在老年人群中男性患病率增加.
- 胀的腺体/眼睛是最常见的症状 (42.79%). 胰腺和胆道经常受到影响.
- 单独使用GC治疗的疗效率为91.82%,复发率为31.46%,而联合治疗的疗效率为88.52%,复发率为19.61%.
- 年龄较小 (<50岁),大动脉和淋巴结的参与与不响应和复发有关. 低血清C4和高器官数量也预测了复发.
结论:
- IgG4-RD的临床表现因年龄和性别而异.
- 涉及的器官数量与血清IgG4度相关.
- 年轻的年龄,低C4,广泛的器官参与和淋巴腺病是IgG4-RD复发的关键预测因素.
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