2型细胞因子和硬质皮质症间歇性肺病
Chiara Pellicano1, Lorenzo Vantaggio1, Amalia Colalillo1
1Department of Translational and Precision Medicine, Sapienza University of Rome, Viale Dell'Università 37, 00185, Rome, Italy.
Clinical and experimental medicine
|July 1, 2023
概括
升高的2型 (Th2) 细胞因子水平,特别是IL-4,与系统性硬化症 (SSc) 中的间歇性肺病 (ILD) 有关. 这些Th2细胞因子可能驱动早期的SSc-ILD.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 类风湿病学 类风湿病学
背景情况:
- 间歇性肺病 (ILD) 是系统性硬化症 (SSc) 的严重并发症.
- 2型 (Th2) 细胞因子与呼吸道炎症和疾病进展有关.
- 了解Th2细胞因子在SSc-ILD中的作用对于开发向疗法至关重要.
研究的目的:
- 评估SSc-ILD患者的Th2介质蛋白 (ILs) 和化学蛋白的血清水平.
- 调查Th2细胞因子水平与肺功能参数之间的相关性,包括对一氧化碳 (DLco) 和高分辨率计算机断层扫描 (HRCT) 发现的扩散肺容量.
- 确定与SSc-ILD存在和严重程度相关的Th2细胞因子.
主要方法:
- 来自60名SSc患者和20名健康对照 (HC) 的血清样本被分析为IL-4,IL-5,IL-11,IL-13,IL-21,IL-31和CXCL-13,使用Bio-Plex多重免疫测试.
- 在SSc患者身上进行了包括DLco和HRCT在内的肺功能测试.
- ILD是由HRCT上的纤维变化定义的,使用CALIPER软件量化.
主要成果:
- 与HC相比,SSc患者的血清Th2细胞因子水平显著更高.
- 在HRCT和IL-13,IL-21,IL-31,IL-4和IL-5上的磨砂玻璃不透明度之间发现了显著的线性相关性.
- 在DLco和IL-4之间观察到负相关性,以及外周血液中乙氨基酸细胞.
- 后勤回归确定IL-4与减少DLco和ILD的存在独立相关.
结论:
- Th2炎症,特别是由IL-4驱动的,在SSc-ILD的早期阶段起着重要作用.
- 升高的IL-4水平与SSc患者的肺功能受损和纤维变化有关.
- 这些发现表明,向Th2细胞因子可能是SSc-ILD的有希望的治疗策略.
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