光学连贯性断层扫描血管学发现,在儿科患者严重的眼科病症
Kubra Serbest Ceylanoglu1, Emine Malkoc Sen2, Selin Sahin Karamert3
1University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey. kubraceylanoglu@gmail.com.
International ophthalmology
|July 1, 2023
概括
儿童的格雷夫斯眼病 (GO) 可能会影响视网膜神经纤维层 (RNFL) 厚度,特别是在下象限. 然而,在斑点和周围斑点区域的微血管结构在很大程度上不受这种情况的影响.
科学领域:
- 眼科医生 眼科 眼科
- 儿科内分泌学 儿科内分泌学
- 医疗成像医学成像
背景情况:
- 格雷夫斯眼病 (GO) 是一种影响甲状腺的自身免疫性疾病,经常导致眼部并发症.
- 儿童GO病例需要特殊评估,因为视觉系统正在发育.
- 了解微血管和神经纤维层的变化对于早期诊断和管理至关重要.
研究的目的:
- 评估GO儿童的周围毛囊和黄斑微血管结构.
- 为了评估儿童GO患者视网膜神经纤维层 (RNFL) 厚度概况.
- 为了将眼部发现与疾病活动和严重程度相关联.
主要方法:
- 18名GO儿童 (36只眼睛) 与20名年龄和性别匹配的对照组 (40只眼睛) 的前性比较.
- 疾病的严重程度和活动使用欧洲格雷夫斯眼科医生组 (EUGOGO) 标准和临床活动评分 (CAS) 进行评估.
- 光学连贯断层扫描 (OCT) 和OCT血管扫描 (OCTA) 用于分析RNFL厚度,黄斑毛细血管 (表面和深层),叶无血管区 (FAZ) 参数和周毛细血管微血管.
主要成果:
- 在GO患者和对照人群之间,周围毛囊或黄斑微血管结构没有显著差异.
- 与对照组相比,在GO患者的下象限中观察到RNFL厚度的统计显著减少 (p=0.03).
- 所有GO患者呈现轻度和不活跃的疾病.
结论:
- 在儿童中,格雷夫斯眼病并没有显著影响周周和黄斑血管参数.
- 下性RNFL厚度是小儿病例中GO的潜在指标.
- 需要进一步的研究来了解这些RNFL变化的长期影响.
相关概念视频
Glaucoma: Overview
629
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
629
Open Angle Glaucoma: Treatment
481
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
481
Imaging Studies VII: Vascular Imaging
32
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
32
Angle Closure Glaucoma: Treatment
575
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
575
Imaging Studies III: Computed Tomography
29
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
29
Aneurysm II: Clinical Manifestations and Diagnostic Studies
10
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
10


