在高分辨率下对人类大脑中弱电流诱导的磁场进行体积测量
Cihan Göksu1,2, Fróði Gregersen1,3,4, Klaus Scheffler2,5
1Danish Research Centre for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, Copenhagen, Denmark.
Magnetic resonance in medicine
|July 1, 2023
概括
卷度MR电流密度成像 (MRCDI) 现在提供高灵敏度和图像质量,用于绘制大脑中跨电刺激 (TES) 的图像. 这一进步改善了临床应用的当前分布分析.
科学领域:
- 医疗成像医学成像
- 神经科学是一个神经科学.
- 电气工程 电气工程
背景情况:
- 临床跨电刺激 (TES) 需要精确了解大脑电流分布.
- MR电流密度成像 (MRCDI) 测量TES诱导的磁场,以绘制电流流的地图.
- 以前的MRCDI方法仅限于人类的单片成像,阻碍了体积分析.
研究的目的:
- 通过3D直线采样 (3D-DENSE) 和同时多切片采集 (SMS-SPARSE) 来推进MRCDI的体积覆盖.
- 优化和验证这些体积测量方法用于体内人脑成像.
- 与2D-MRCDI相比,评估灵敏度和图像质量的改进.
主要方法:
- 开发和优化3D-DENSE和SMS-SPARSE MRCDI技术. 这些技术包括:
- 使用电缆循环实验进行验证.
- 使用常见的电极组装在人体中使用1-mA TES进行测试.
- 与传统的2D-MRCDI进行体积测量方法的比较.
主要成果:
- 3D-DENSE显示,尽管采集时间较长,但该领域的拉普拉斯基灵敏度提高了61%.
- 具有2倍CAIPIRINHA加速的SMS-SPARSE表现出卓越的性能.
- 在基线时,SMS-SPARSE实现了56% (现场) 和78% (拉普拉西安) 的灵敏度改善,并在当前注射期间实现了43% (现场) 和55% (拉普拉西安) 的灵敏度改善.
- 在10分钟内,SMS-SPARSE在3个切片 (2x2x3mm^3分辨率) 中达到67 pT的灵敏度,图像质量得到了持续的提高.
结论:
- 卷度MRCDI方法,特别是SMS-SPARSE,提供高灵敏度和图像质量.
- 这些先进的技术非常适合在人类大脑中描述TES场分布.
- 这使得TES可以更准确地用于治疗和研究目的.
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