和睡眠特征与患有的老年人24小时记忆能力的减弱有关
Rani A Sarkis1, Alice D Lam2, Milena Pavlova1
1Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Epilepsia
|July 1, 2023
概括
患有的老年人经历记忆力下降,由更频繁的间接性型活动 (IEA) 和更高的抗药物负担 (ASM) 恶化. 缓慢波活动 (SWA) 的减少也会影响这一群体的记忆保留.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 老年病的医生 老年病的医生
背景情况:
- 经常与认知障碍,特别是记忆障碍有关.
- 患有的老年人特别容易患有记忆力缺陷,这是由于衰老和的联合影响.
研究的目的:
- 在被诊断为的老年人中调查与24小时记忆保留相关的因素.
- 在这个人口群体中确定改善记忆功能的潜在治疗点.
主要方法:
- 一组55名患有的50岁以上的成年人接受了一项声明性记忆任务,评估24小时后的回忆.
- 健行电脑电图 (EEG) 监测被用来评估间歇性活动 (IEA) 和睡眠模式,包括慢波活动 (SWA).
- 用多变量回归分析来确定记忆保留的预测因素,控制年龄,性别和教育程度.
主要成果:
- 最后的研究组包括42名参与者,平均年龄为64.3岁,平均24小时记忆保留率为70.9%.
- 间歇性型活动 (IEA) 的频率增加与24小时内存保留能力较差显著相关 (β = -0.08,p = 0.0094).
- 更多的抗发作药物 (ASM) (β = -0.20,p = 0.013) 和睡眠期间减少的全球慢波活动 (SWA) 功率 (β = +0.002,p = 0.02) 也与更糟糕的记忆回忆有关.
结论:
- 在患有的老年人中,更高的IEA频率,降低的SWA功率和更高的ASM负担与减少24小时记忆保留有关.
- 这些发现突出了IEA,SWA和ASM负载作为旨在增强患者老年人记忆力的干预措施的潜在目标.
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