环境温度暴露导致肺功能受损:健康受试者受控温度研究 (CTSHS) 的证据
Weihong Qiu1, Heng He2, Lieyang Fan3
1Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350122, China; Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
暴露于极端温度显著影响肺功能,增加炎症和氧化应激. 特别是低温与肺容量降低和炎症标志物升高有关.
科学领域:
- 环境健康 环境健康
- 肺部医学 肺部医学
- 毒理学 毒理学 毒理学
背景情况:
- 不理想的环境温度 (低和高) 对肺功能及其机制的影响尚未完全理解.
- 之前的研究还没有全面研究对受控温度暴露的生理反应.
研究的目的:
- 研究环境低温和高温对肺功能参数的影响.
- 确定与温度诱导的肺功能变化相关的潜在机制,包括炎症和氧化应激标志物.
主要方法:
- 在受控空气污染条件下,健康的志愿者 (n=43) 被暴露在中度 (18°C),低度 (6°C) 和高度 (30°C) 温度下12小时.
- 分析了肺功能 (FVC,FEV1,PEF),血液和尿液样本的炎症和氧化损伤标志物.
- 统计分析包括混合效应模型和重复测量相关性.
主要成果:
- 低温降低了FVC和FEV1分别为2.20%和2.59%,并增加了PEF的5.68%. 高温降低了FVC的1.59%并增加了PEF的7.29%.
- 低温导致炎症标志物 (PCT,PLR,NLR) 和氧化损伤标志物 (8-isoPGF2α,8-OHdG) 的增加. 高温导致HNE-MA升高.
- 在低温下,炎症标志物 (PCT,NLR) 和氧化损伤标志物 (HNE-MA,8-OHdG) 与肺功能参数 (FVC,FEV1) 有负相关性.
结论:
- 不理想的环境温度会改变肺功能,炎症和氧化损伤.
- 炎症和氧化损伤与在低温下观察到的肺功能减少有关.
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