认知对功能网络完整性的依赖随着年龄的增长而取决于结构网络完整性的条件
Xulin Liu1, Lorraine K Tyler2, Cam-Can3
1Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Neurobiology of aging
|July 1, 2023
概括
大脑网络的完整性,特别是结构和功能连接之间的对齐,是维持终身认知功能的关键,特别是在老年人中. 这种大脑连接支持健康的衰老.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 脑部成像 脑部成像
背景情况:
- 认知功能对于终身福祉至关重要.
- 大脑功能依赖于大脑网络内部和大脑网络之间的相互作用.
- 白物质架构形成结构性大脑网络,影响功能网络.
研究的目的:
- 研究功能和结构性大脑连接的融合以及它们之间的分歧如何影响成年人一生中的认知维护.
- 为了确定大脑连接模式和认知概况之间的关系.
- 了解衰老如何影响大脑对认知功能连接的依赖.
主要方法:
- 利用多变量分析来检查功能结构连接性趋同与认知特征的分歧之间的联系.
- 使用神经成像技术 (隐含) 评估大脑网络连接.
- 分析了不同年龄组的认知表现.
主要成果:
- 认知功能显示,随着年龄的增长,对功能结构连接性趋同的依赖性越来越大.
- 这种依赖性在高阶皮质和皮质下网络中最为明显.
- 由结构连接支持的大脑功能网络完整性,对于维持老年人的认知能力至关重要.
结论:
- 大脑结构连接的完整性支着功能网络的完整性.
- 大脑网络的完整性对于维持认知功能至关重要,特别是在晚年.
- 与年龄相关的认知维护受到大脑结构和功能之间的对齐的影响.
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