排便频率,便一致性和致残性痴呆的风险:一项基于日本人口的队列研究
Y Shimizu1, M Inoue2, N Yasuda3
1Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
中年人的排便习惯,包括不太频繁的排便和更硬的便,与痴呆症的风险增加有关. 这一发现突出了男性和女性认知能力下降的潜在早期指标.
科学领域:
- 老年学是指老年学的学科.
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 中年健康标志物越来越多地被认为具有对长期认知健康的预测价值.
- 了解生理功能和神经结果之间的关系对于预防策略至关重要.
研究的目的:
- 调查中年人的肠道习惯与随后发展痴呆症的风险之间的联系.
- 分析肠道排便频率和便的一致性作为痴呆症的潜在预测因素.
主要方法:
- 一项基于人口的队列研究,利用日本国家长期护理保险记录.
- 从2006年至2016年,对发生痴呆症的19396名男性和22859名50-79岁的女性进行了跟踪.
- 考克斯的比例危险模型被用来计算风险比率 (HRs),调整了生活方式和病史.
主要成果:
- 下肠运动频率 (BMF) 与男性和女性痴呆症风险显著增加有关.
- 男人有<3 BMF/周的调整HR为1.79,女性的调整HR为1.29与每天一次相比.
- 更硬的便一致性也与痴呆症风险增加相关,调整后的HR在男性高达2.18和女性高达1.84的非常硬的便.
结论:
- 减少肠道排便频率和中年更硬的便独立地与痴呆症风险增加有关.
- 这些肠道习惯指标可能成为潜在的认知障碍早期预警信号.
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