在日本一家三级医院的眼球角膜炎:一个10年的单中心回顾性研究
Tomoya Sano1, Hisashi Sasaki1, Yohei Maki1
1Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, 359-8513, Japan.
概括
眼球角膜炎的趋势显示,Candida albicans是常见的病因,物种多样化和药物耐药性增加. 及时的眼科检查和量身定制的抗真菌治疗对于管理这种危及视力的候选血症并发症至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 医学真菌学 医学真菌学
背景情况:
- 眼球角膜炎是白血病的严重并发症,可能导致视力丧失.
- 了解致病物种和抗真菌易感性的趋势对于有效治疗至关重要.
- 之前的研究强调了早期眼科咨询和抗真菌治疗的重要性.
研究的目的:
- 分析患有候选血症的患者眼球候选症的趋势.
- 为了确定临床特征,致病物种和抗真菌敏感性模式.
- 评估受影响患者的治疗结果和视力敏度.
主要方法:
- 从2010年至2020年进行眼科查的80名白血病患者的回顾性分析.
- 眼球角膜炎 (n=29) 和非眼球角膜炎 (n=51) 组之间的临床数据比较.
- 对致病的Candida物种,抗真菌敏感性和治疗结果的分析.
主要成果:
- 中枢静脉导管插入 (82.8%) 和Candida albicans (72.4%) 在眼球白症组显著更常见.
- 大多数眼球角膜炎病例无症状,并通过抗真菌疗法得到改善;其中一个需要进行玻璃切除术.
- 从2016年至2020年观察到的物种多样化,Candida parapsilosis的减少和Candida glabrata和Candida tropicalis的增加.
- 针对关键的Candida物种,诺甘丁和5-光细胞素的最小抑制度略有增加.
结论:
- 眼科检查对于诊断眼球候群症至关重要.
- 抗真菌剂的选择应考虑Candida物种的不断变化的多样性及其对药物的敏感性.
- 监测候选血症和眼部干扰的趋势对于调整治疗策略至关重要.
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