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具有异常四肢环的多糖化物,具有来自黑狼的抗帕金森病潜力

Yi-Kao Hu¹, Xiao-Lin Bai¹, Guang-Yu Shi¹

¹Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China; University of Chinese Academy of Sciences, Beijing, 100049, China.

|July 1, 2023

概括

梅瑞果的Lycium ruthenicum果实产生了七种新的多基化物. 三种化合物显示出显著的神经保护作用,抑制单胺氧化酶B,并有利于帕金森病.

科学领域:

自然产品化学自然产品化学
神经药理学神经药理学
医学植物学医学植物学

背景情况:

传统上,Lycium ruthenicum Murray (黑色古吉果) 是用于健康益处的.
聚基化物是众所周知的多种生物活动.
像帕金森病这样的神经退行性疾病需要新的治疗药物.

研究的目的:

从L. ruthenicum穆雷果实中分离和描述新型化合物.
评估孤立化合物的神经保护潜力.
为了研究作用机制,包括单胺氧化酶B抑制.

主要方法:

使用色谱技术进行隔离和净化.
通过综合光谱分析 (IR,HRESIMS,NMR,ECD) 和化学水解来阐明结构.
在体外测试中检测PC12细胞中对6-OHDA的单胺氧化酶B抑制和神经保护.
在体内研究中使用了帕金森病的Drosophila melanogaster模型 (PINK1B9).

主要成果:

确定了7种新的多糖化物 (1-7) 和14种已知的化合物 (8-21).
化合物1-3显著抑制了单胺氧化酶B (IC50值在25.12至35.36μM之间).
化合物1-3在PC12细胞中表现出神经保护作用,而化合物1在中改善了帕金森病模型表型.

结论:

这项研究成功地从L. ruthenicum Murray中分离和表征了新型的多基化物.
化合物1-3具有显著的神经保护性质,部分是通过抑制单胺氧化酶B.
L. ruthenicum 穆雷果实显示出作为天然神经保护剂的来源的潜力,特别是对于帕金森病.

关键词:

抗帕金森病效应的抗帕金森病效应.黑狼是一种黑狼.莱西 (Lycium ruthenicum) 是一种有毒的植物.聚醇糖化物是多种类型的糖化物.鲁氨酸 A−C - 鲁氨酸这是Solanaceae.

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