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在3小时口服葡萄糖耐受性测试中的一个异常值与双胞胎妊娠中的不良周产期结果之间的关联

Tzuria Peled¹, Hen Y Sela¹, Ari Weiss¹

¹Department of Obstetrics & Gynecology, Shaare Zedek Medical Center, Affiliated with the Hebrew University School of Medicine, Jerusalem, Israel.

Diabetes research and clinical practice

|July 1, 2023

概括

双胞胎妊娠和一个异常口服葡萄糖耐受性测试 (OGTT) 结果的妇女面临更高的新生儿不良结果的风险,包括早产和新生儿发病率. 需要进一步的研究来探索对这一高风险群体的干预措施.

科学领域:

周围生理学周围生理学
孕产妇和胎儿医学孕产妇和胎儿医学
内分泌学在内分泌学.

背景情况:

双胞胎怀孕与不良周产期结果的风险增加有关.
妊娠期糖尿病 (GDM) 查对于识别风险妊娠至关重要.
边界异常葡萄糖耐受性测试结果在双胞胎怀孕中的意义需要进一步调查.

研究的目的:

评估双胞胎怀孕与一个异常的3小时口服葡萄糖耐受性测试 (OGTT) 值和不良周产期结果之间的关联.
为了在不同OGTT结果类别中比较双胞胎妊娠的女性的结果.

主要方法:

这是一项回顾性多中心研究,涉及2597名双胞胎妊娠的妇女.
四组的比较:正常的屏幕,正常的3小时OGTT,一个异常的3小时OGTT和GDM.
多变量逻辑回归分析,以关键混因素进行调整.

主要成果:

具有一个异常OGTT值的女性显示出显著更高的早产率 (<32周) 和孕期新生儿的大.
复合新生儿发病率更频繁地发生在来自母亲的一个异常OGTT值的新生儿中.
具有一个异常OGTT值的女性和具有正常屏幕的女性之间,母亲的结果是相似的.

结论:

双胞胎怀孕中有一个异常的3小时OGTT值与不良新生儿结果的风险增加有关.
这些发现突出了双胞胎怀孕中的特定高风险组,需要进一步关注.
干预研究是有必要的,以确定管理策略是否可以改善这一群体的围产期结果.

关键词:

血糖监测血糖监测血糖监测血糖监测孕期糖尿病 (GDM) 是一种孕期糖尿病.过高血糖症的发生.葡萄糖耐受性受损的情况.母亲的结果.新生儿结局的结果.营养咨询营养咨询 OGTT (口服葡萄糖耐受性测试) 是一种口服葡萄糖耐受性测试.周产期发病率周产期发病率双胞胎怀孕双胞胎怀孕时间

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