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制药瓶中的微塑料和液材料:在Donax faba (海) 的体内研究

Zachariah Sunil¹, John Thomas¹, Amitava Mukherjee¹

¹Centre for Nanobiotechnology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, India.

Environmental toxicology and pharmacology

|July 1, 2023

概括

药品瓶中的化学物质会损害海洋生物. 研究表明,液中的重金属和有机物对Donax faba的抗氧化系统产生负面影响,这表明人类健康存在潜在风险.

科学领域:

环境毒理学环境毒理学
海洋生物学海洋生物学
聚合物科学聚合物科学

背景情况:

药品通常储存在合成聚合物瓶中,主要是聚乙烯二甲 (PET).
这些容器中的液对海洋生物的潜在毒理影响尚未完全理解.
了解这些影响对于评估环境和人类健康风险至关重要.

研究的目的:

为了研究药品容器液对海洋双鱼Donax faba的毒理影响.
识别和量化液中存在的有机和无机化合物.
评估浸出水暴露对D. faba.抗氧化剂防御系统的影响.

主要方法:

溶液成分的分析,包括重金属,有机和无机物质.
暴露Donax faba在水中的情况.
生物化学试验用于测量蛋白质度,活性氧物种 (ROS),马隆迪化物 (MDA),超氧化物转化酶 (SOD) 和催化酶 (CAT) 水平.

主要成果:

与饮用水标准相比,液含有高度的重金属.
暴露生物中的蛋白质度增加了8.5%.
ROS水平增加了3倍,MDA增加了4.3%,而SOD和CAT分别减少了14%和70.5%,表明氧化应激和对抗氧化机制的损伤.

结论:

药品容器液对Donax faba的抗氧化防御系统产生不利影响.
重金属和其他液化合物的存在对海洋生态系统构成毒理风险.
聚乙烯 (PET) 制药容器可能会泄露有害的添加剂,可能会对包括人类在内的更高生物体造成氧化和代谢损害.

关键词:

抗氧化剂是一种抗氧化剂.致癌物质是致癌物质.这是一种重金属,重金属.溶解液是一种溶解液.变异原体是发生变异的诱因.

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