布拉迪心律失常症在心脏粉症中的作用和节拍器的作用
Syed Bukhari1, Amail Kasi2, Bilal Khan3
1Department of Medicine, Temple University Hospital, Philadelphia, PA.
Current problems in cardiology
|July 1, 2023
概括
心脏粉症 (CA) 经常导致由于粉样纤维的沉积而导致肌节律失调. 虽然起器提供症状缓解,但双心室治疗可能是管理CA患者传导系统疾病进展的更安全选择.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 氨基粉症研究研究
背景情况:
- 心脏氨基粉症 (CA) 是一种被诊断不足的疾病,其特征是心肌中氨基粉纤维的沉积.
- 粉样蛋白沉积会破坏心脏传导系统,经常导致心律失常.
- 在CA中,心房导电缺陷比节功能障碍更为常见.
研究的目的:
- 总结心脏粉样性粉症中勃拉迪亚律律症的患病率和管理.
- 为了比较不同类型的CA (ATTR和AL) 中的勃拉迪亚心律失常的发病率.
- 讨论CA中节拍疗法的作用和局限性.
主要方法:
- 对心脏粉症和相关心律失常的现有文献的综述.
- 分析野生类型的转化腺素 (wtATTR),遗传性转化腺素 (hATTR) 和轻链 (AL) 氨基粉症的布拉迪亚律症的患病率.
- 对心脏起器植入和心脏再同步治疗的疗效和适应症的评估.
主要成果:
- 布拉迪心律失常在CA中很常见,在wtATTR,hATTR和AL类型中患病率各不相同.
- 心脏起器植入提供症状缓解,但没有死亡率的好处.
- 导管系统疾病往往会进展,增加节奏负担,有利于双心室治疗.
结论:
- 勃拉迪心律失常是心脏粉症的一个显著的临床表现.
- 心脏起器植入用于缓解症状,但由于疾病进展,双心室治疗可能会提供更好的结果.
- 根据目前的指导方针,不建议在CA患者中进行预防性心脏起器植入.
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