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Updated: Jul 24, 2025

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通过半理性工程提高SceCPR的催化效率,以实现D-pantolactone的不对称减少

Man Zhao1, Bin Zhou1, Xiaoli Jia1

  • 1Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China; The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.

Journal of biotechnology
|July 1, 2023
PubMed
概括

来自Saccharomyces cerevisiae (SceCPR) 的基因工程基托潘托拉克 (KPL) 减少酶显示出显著增强的活性,用于产生D-潘托拉克 (D-PL),这是一个关键的性中间体. 突变SceCPR ((S158A/Y298H) 突变使催化效率提高了18.5倍.

关键词:
催化剂口袋是一种催化剂.这是一种D-pantolactone.凯托潘托拉克减少酶.局部导向的突变发生.整个细胞的催化作用.

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