相关实验视频

Updated: Jul 24, 2025

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Published on: July 12, 2024

牙状的微观结构与暴露于两个人类队列中的母亲压力后的弹性有关

Milenna T van Dijk¹, Ardesheer Talati¹, Pratik Kashyap²

¹Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York.

Biological psychiatry

|July 1, 2023

概括

母亲的压力与后代的牙状 (DG) 微观结构的变化有关,这与以后的抑郁症状有关. 这表明总局在母亲的压力如何影响情绪发展方面发挥了作用.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
精神病学是一个精神病学.

背景情况:

孕产妇的压力 (MS) 是众所周知的不良后代情绪发展的危险因素.
动物研究表明,牙状 (DG) 参与其中,但人类的机制尚不清楚.
这项研究调查了MS和后代抑郁症状和GD变化之间的关联.

研究的目的:

检查母亲的压力和后代的抑郁症状之间的关系.
为了调查母亲的压力是否与后代的牙状的微观结构和宏观结构变化有关.
探索牙状回形在调解母亲压力对后代心理健康的影响中的作用.

主要方法:

扩散张力成像 (DTI) 用于分析两个独立队列 (TGS和ABCD研究) 的牙状平均扩散率 (DG-MD) 和体积.
使用了通用估计方程模型和调解分析.
使用经过验证的问卷来评估母亲的压力,并使用患者健康问卷-9测量后代的抑郁症状,反秤和儿童行为检查清单.

主要成果:

孕产妇的压力与后代的DG-MD增加有关 (表明受损的微观结构) 和未来的抑郁症状在两个队列.
在后续评估中,更高的DG-MD与更高的症状得分相关.
在ABCD研究中,在高母亲压力后出现抑郁症状的后代中,特别观察到高的DG-MD,这将他们与弹性后代区分开来.

结论:

来自两个独立样本的研究结果支持牙状在母亲压力对发育影响中的作用.
这些结果与动物研究一致,表明DG是受母亲压力影响的关键大脑区域,与后代抑郁症有关.
这项研究为人类提供了神经生物学机制的证据,这些机制是母亲压力对情感健康的代际影响的基础.

关键词:

在 DTI 中,DTI 是指DTI.牙的牙周 (Dentate Gyrus) 是一个牙周.抑郁症抑郁症抑郁症在海马体内,海马体这就是为什么MRI是MRI.孕产妇的压力就是母亲的压力.恢复力恢复力易感性易感性易感性

更多相关视频

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Published on: June 10, 2013

相关概念视频

Psychological Responses to Stress

Psychological Responses to Stress

Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...

Functional Brain Systems: Limbic System

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...