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微生物代谢物通过BNST中的CaMKII神经元调节社会新奇性

Chia-Wei Liou¹, Sin-Jhong Cheng², Tzu-Hsuan Yao³

¹Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Rd, Tainan 70101, Taiwan; Department of Physiology, College of Medicine, National Cheng Kung University, 1 University Rd, Tainan 70101, Taiwan.

Brain, behavior, and immunity

|July 1, 2023

概括

肠道微生物通过代谢产物影响社会行为. 传送到大脑的短链脂肪酸 (SCFA) 通过影响末端 (BNST) 床核中的特定神经元来破坏社会新奇.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
行为科学行为科学

背景情况:

社会新性对于战略性同类互动至关重要.
众所周知,肠道微生物群的代谢物,如短链脂肪酸 (SCFA),会影响宿主行为.
调解这些效应的精确神经通路在很大程度上仍未被探索.

研究的目的:

调查SCFA直接输送到大脑对社会新奇性的影响.
确定参与SCFA介导的社会行为调制的特定神经元群和大脑区域.
在这个过程中探索终端细胞 (BNST) 床核的作用.

主要方法:

将SCFA注入微生物贫乏小鼠的侧腔室.
在BNST中激活和化学遗传沉默/卡尔莫杜林依赖蛋白激酶II (CaMKII) 标记的神经元.
在BNST中药理上抑制脂肪酸氧化.

主要成果:

在没有诱导脑炎的小鼠中,SCFA的直接脑输液扰乱了微生物群贫乏的社会新奇.
在BNST中激活CaMKII标记的神经元复制了社会新奇缺陷.
沉默这些神经元或抑制脂肪酸氧化在BNST逆转SCFA诱导的赤字.

结论:

微生物代谢产物,特别是SCFA,通过BNST内的独特的神经元群体直接影响社会新性.
在BNST中的CaMKII标记的神经元是SCFA对社会新奇性影响的关键调解者.
这项研究阐明了一种新的肠-大脑轴路径,影响社会行为.

关键词:

末 (BNST) 的床核 /卡尔莫杜林依赖性蛋白激酶II (CaMKII) 是一种/卡尔莫杜林依赖性蛋白激酶.大脑脊髓液 (CSF) 是一种脂肪酸氧化过程中的脂肪酸氧化.肠-大脑轴肠-大脑轴肠道衍生代谢物的代谢物.侧心室的侧心室微生物群中的微生物群短链脂肪酸 (SCFA) 是一种脂肪酸.社会新性社会新性

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