在极度早产的儿童中,学龄的视网膜结构和视觉通路功能:基于人口的研究.
Sigrid Hegna Ingvaldsen1,2, Kyrre Moljord3,4, Arnstein Grøtting5
1Department of Neuromedicine and Movement Science, NTNU Norwegian University of Science and Technology, Trondheim, Norway. sigrid.h.ingvaldsen@ntnu.no.
BMC ophthalmology
|July 1, 2023
概括
极度早产的儿童表现出持续的视网膜和视觉通路不成熟. 更薄的视网膜层与延迟的视觉唤起的潜在延迟相关,表明持续的发展需求.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
背景情况:
- 极度早产婴儿 (<28周) 经常表现出视力功能减弱,即使没有诊断出新生儿疾病.
- 这项研究研究了极其早产的学龄儿童的视网膜结构和视觉通路功能.
研究的目的:
- 通过光学连贯断层扫描 (OCT) 评估视网膜结构,并通过模式逆转视觉唤起潜能 (PR-VEP) 评估视觉功能.
- 在这个群体中探索视网膜结构和视觉通路功能之间的关联.
主要方法:
- 使用OCT,OCT血管学 (OCT-A) 和PR-VEPs检查了36名极早产儿 (出生于2006-2011).
- 测量了状血管区域 (FAZ),黄斑血管密度/流量 (OCT-A),视网膜神经纤维层 (RNFL) 和内状团细胞层 (IPGCL) 厚度 (OCT).
- 对N70-P100的振幅和延迟进行了评估PR-VEP.
主要成果:
- 与参考人群相比,参与者表现出异常的视网膜结构和延迟的P100延迟.
- 在P100延迟和RNFL/IPGCL厚度之间发现了负相关性.
- 患有早产视网膜病变 (ROP) 的儿童具有更小的FAZ,改变的黄斑血管性,以及更薄的RNFL/IPGCL.
结论:
- 没有脑损伤后果的极度早产儿表现出不成熟的视网膜血管和神经视网膜层的迹象.
- 更薄的神经网膜层与延迟的P100延迟有关,这表明持续视觉通路的发展至关重要.
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