统计剂使用与脂蛋白增加的关联:一个真实世界的数据库研究研究
Tienan Feng1,2, Yao Li3, Xiongfeng Xue4
1Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
European journal of medical research
|July 1, 2023
概括
立方体使用显著增加脂蛋白[Lp]水平,这是潜在的心血管风险. 这项现实研究证实了这一关联,强调了进一步临床研究的必要性.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 越来越多的人担心他类药物可能会增加脂蛋白 (a) [Lp (a) ]水平.
- 需要现实世界的证据来调查他类药物使用和Lp (a) 水平之间的关联.
研究的目的:
- 为了研究他类药物使用和脂蛋白[Lp]水平的变化之间的关联,在一个大型现实世界队列中.
- 为了确定他类药物治疗是否与升高的Lp (a) 水平有关.
主要方法:
- 这是一项回顾性队列研究,利用来自221家中国医院的大型综合数据库.
- 倾向性得分匹配 (1:1比) 用于将他类药物使用者 (42,166名患者) 与非他类药物使用者进行比较.
- 对纵向随访数据的分析,包括Lp (a) 水平,以计算Lp (a) 变化的危险比率.
主要成果:
- 当低密度脂蛋白胆固醇 (LDL-C) 水平相似时,他类药物的使用与增加的Lp(a) 水平显著相关 (调整HR 1.47;95%CI 1.43-1.50).
- 升高的Lp (a) 在不同小组和不同患者队列中是一致的.
- 较高的他类药物剂量强度与增加的Lp (a) 水平呈正相关.
结论:
- 与非他类药物使用相比,他类药物治疗与Lp (a) 升高的风险增加有关.
- 类他类药物诱导的Lp (a) 增加的临床意义需要在临床试验中进一步评估.
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