急性至慢性肝衰竭:还有很长的路要走 - - 综述
Jinjin Luo1, Jiaqi Li1,2, Peng Li1
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou, 310003, China.
Critical care (London, England)
|July 1, 2023
概括
急性至慢性肝衰竭 (ACLF) 是一种严重的综合症,死亡率高. 标准化诊断标准和治疗策略对于改善ACLF患者的治疗结果至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
- 临床综合征 临床综合征
背景情况:
- 急性至慢性肝衰竭 (ACLF) 是一种严重的临床综合征.
- 慢性肝病的急性恶化,器官衰竭和高短期死亡率的特征.
- 由于各种病因,全球存在不同的定义和诊断标准.
研究的目的:
- 审查目前对ACLF的理解.
- 突出需要标准化诊断标准和治疗范式的需要.
- 强调针对性治疗解决潜在的病理生理学的重要性.
主要方法:
- 审查关于ACLF定义,诊断和预后的现有文献.
- 对目前关于ACLF病理生理学的证据的分析.
- 讨论对治疗标准化的需要.
主要成果:
- 在不同地区,ACLF的定义和标准各不相同.
- 已经开发了预测和预后得分.
- 病理生理学与强烈的全身炎症和免疫代谢障碍有关.
结论:
- 需要对ACLF诊断和治疗进行标准化.
- 需要针对不同疾病阶段制定有针对性的治疗策略.
- 对ACLF病理生理学的进一步研究将指导个性化医学.
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