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对于检测库辛病中的皮质otropinomas的PET的实用性:一个范围审查审查

Megan M J Bauman^1,2, Jeffrey P Graves^1,3, Daniel Jeremiah Harrison^1,2

¹Mayo Clinic Alix School of Medicine, Rochester, MN, USA.

Neurosurgical review

|July 1, 2023

概括

定子发射断层扫描 (PET) 显示出诊断库辛病的前景,特别是当磁共振成像 (MRI) 无法得出结论时. MET PET具有很高的准确性,而FET PET和68 Ga-DOTA-CRH PET需要进一步研究以检测下垂体腺瘤.

科学领域:

核医学是一种核医学.
内分泌学在内分泌学.
放射学放射学是一门学科.

背景情况:

磁共振成像 (MRI) 是诊断库辛病的标准,但具有局限性,在高达40%的病例中无法检测腺瘤.
定子发射断层扫描 (PET) 正在成为检测库辛病中的垂体腺瘤的宝贵工具.

研究的目的:

进行范围审查,描述各种PET模式对库辛病的诊断效用.
定义PET阳性疾病并评估PET的性能,特别是在MRI阴性病例中.

主要方法:

根据PRISMA-ScR指南进行范围审查.
包括31项研究 (10项前性研究,8项后性研究,11项病例报告,2项说明性病例) 涉及262名患者.
分析通常使用的PET方式,包括FDG PET,MET PET,68 Ga-DOTATATE PET,13N-氨PET和68 Ga-DOTA-CRH PET.

主要成果:

PET阳性范围从36%到100%,而MRI阳性范围从13%到100%.
在MRI阴性病例中,PET阳性从0%到100%不等.
报告的PET灵敏度和特异性分别在36%至100%和50%至100%之间. MET PET显示出极好的灵敏度和特异性.

结论:

PET成像对检测库辛病中的皮质otropinomas具有显著的前景,包括在MRI阴性的情况下.
MET PET是一种经过充分研究的模式,具有被证明的高精度.
新兴的PET标记物如FET PET和68 Ga-DOTA-CRH PET显示出高诊断性能的潜力,需要进一步的研究.

关键词:

库辛病是什么病?库辛病是什么病?核磁共振 - 阴性核磁共振阴性库希氏病库希氏病下垂体 - - 下垂体定子发射断层扫描 (PET) 是一种定子发射断层扫描.头骨的基础是骨的基础.

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