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多组件认知训练计划BrainProtect在认知健康成年人的影响:随机对照试验

Julia Maria Falkenreck¹, Michelle Celine Kunkler¹, Anja Ophey²

¹Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Journal of Alzheimer's disease : JAD

|July 2, 2023

概括

多组件认知训练 (BrainProtect) 对全球认知没有显著影响,但在健康的老年人中改善了特定的认知功能和生活质量. 需要进一步的研究来证实这些发现.

科学领域:

神经科学是一个神经科学.
认知心理学认知心理学
老年学是一门学科.

背景情况:

认知完整性对整体健康至关重要.
预防认知障碍的策略正在积极研究.
在老年人群中保持认知功能是公共卫生重点.

研究的目的:

评估多组件认知训练计划 (BrainProtect) 与一般健康咨询 (GHC) 对认知能力的短期影响.
评估BrainProtect和GHC对健康老年人与健康相关的生活质量 (HRQoL) 的影响.
将认知训练与认知健康维护的标准健康建议进行比较.

主要方法:

一项并行随机对照试验 (RCT) 涉及132名50岁以上的认知健康成年人.
参与者被分配到BrainProtect (n=60) 或GHC (n=72) 中.
BrainProtect涉及8个每周90分钟的会议,重点是执行功能,注意力,学习,感知,想象力,营养和运动,以及干预前后的评估.

主要成果:

在全球认知的初级终点 (CERAD-Plus-z总分) 中没有观察到显著的改善.
与GHC相比,BrainProtect组表现出语言流性,视觉记忆和视觉构造功能显著改善.
在BrainProtect组中,与健康相关的生活质量 (HRQoL) 显著改善;尽管在调整后失去了统计学意义,但一些变化在临床上是相关的.

结论:

在这项研究中,BrainProtect并没有显著提高全球认知表现.
在特定的认知领域和HRQoL中观察到的改善表明了需要进一步研究的潜在好处.
建议在未来的研究中采用更大的样本大小,以确认BrainProtect在认知增强方面的有效性.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.认知完整性的认知完整性认知训练是一种认知训练.健康的衰老健康的衰老预防预防预防

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