由fusobacterium nucleatum触发的纯素代谢重编程驱动头癌的瘤发生
Feiran Li1, Huiying Huang1, Jing Xu2
1Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen Yang Road, Shanghai, China.
Discover oncology
|July 2, 2023
概括
在头癌中,Fusobacterium nucleatum会改变纯素代谢,影响瘤的进展. 尿酸水平可以作为HNSCC患者的治疗标.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 菌核酸菌 (F. nucleatum) 是一种亲瘤性细菌,与头部和部状细胞癌 (HNSCC) 的预后不佳有关.
- 在HNSCC中,F. nucleatum对代谢重编程和瘤进展的特定影响需要进一步研究.
研究的目的:
- 研究由F.核在HNSCC.中诱导的代谢变化.
- 探索这些代谢变化对HNSCC进展和患者结局的作用.
主要方法:
- 液态染色体质谱法 (LC-MS) 用于分析与F. nucleatum.共同培养的HNSCC细胞系 (AMC-HN-8) 中的代谢物变化.
- 单变体,多变体和KEGG通路丰富分析确定了差异性代谢物和受影响的代谢通路.
主要成果:
- 与F. nucleatum一起培养显著改变了AMC-HN-8细胞的代谢概况.
- purin代谢是最显著丰富的途径,显示了 purin 降解的降低调节.
- 尿酸是一种纯素代谢物,可以逆转F.核诱导的瘤进展,并调节活性氧物种 (ROS) 水平. 在HNSCC患者的血清尿酸和F. nucleatum丰度之间观察到负相关性.
结论:
- 在HNSCC中,F. nucleatum驱动异常的纯素代谢,与瘤进展和预后相关.
- 针对F.核诱导的纯素代谢重编程为HNSCC提供了潜在的治疗策略.
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