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Updated: Jul 24, 2025

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通过重组大肠杆菌细胞在高基底负荷下使用环保离子液作为辅溶剂,高效的非对称合成乙烯 (R) -3-基酸盐

Zhiwen Duan1,2, Yaowu Wang1,2, Bin Ouyang1,2

  • 1Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China.

Bioprocess and biosystems engineering
|July 2, 2023
PubMed
概括

环保的离子液体,胆化物/谷氨 (ChCl/GSH) 和四甲基/氨酸 ([TMA][Cys]) 增强了合成乙烯 (R) -3-酸 (R-EHB) 的生物催化. 这些系统提高了基质溶解性和细胞透性,提高了制药中间体的产量.

关键词:
不对称的生物还原.辅助溶剂是一种辅助溶剂.乙烯 (R) -3-基酸乙烯 (R) -3-基酸乙烯 (R) -3-基酸乙烯 (R) -3-基酸乙烯 (R) -3-基酸乙烯 (Ethyl (R) -3-hydroxybutyrate) 乙烯 (R) -3-基酸乙烯 (Ethyl (R) -3-hydroxybutyrate) 乙烯 (Ethyl (R) -3-hydroxybutyrate) 乙烯 (R) -3-酸乙烯 (Ethyl (R) -3-hydroxybutyrate) 乙烯 (Ethyl) 乙烯 (R) -3-hydroxybutyrate) 乙烯 (Ethyl (R) -3-hydroxybutyrate) 乙烯一个IL缓冲系统IL缓冲系统.整个细胞的催化作用.

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