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Updated: Jul 24, 2025

Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System
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ISRIB可以缓解与衰老相关的棕色脂肪UCP1转化抑制和热原性缺陷

Muze Li1, Mengjie Gao2, Meiqi Jia2

  • 1Department of Occupational and Environmental Health, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, China; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, China; School of Basic Medicine, Fourth Military Medical University, Xi'an, China.

Biochemical and biophysical research communications
|July 2, 2023
PubMed
概括

老龄化会损害棕色脂肪的热生成,增加寒冷压力风险. 一种新的ISR抑制剂 (ISRIB) 恢复了UCP1的功能,增加了热量产生,改善了老年小鼠的代谢健康.

关键词:
衰老的衰老 衰老的衰老棕色的脂肪 棕色的脂肪伊斯里布伊斯里布热生成是一种热生成.翻译效率 翻译效率在UCP1中,UCP1是UCP1.

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