在患有强迫症患者中,后带带皮层自发活动与运动反应抑制有关:静止状态fMRI研究
Hirofumi Tomiyama1, Keitaro Murayama1, Kiyotaka Nemoto2
1Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Japan.
Psychiatry research. Neuroimaging
|July 2, 2023
概括
强迫症 (OCD) 与受损的运动反应抑制有关. 背后带带皮层 (PCC) 的休息状态大脑活动被确定为强迫症患者这种损伤的关键因素.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 抑制运动反应对于日常功能至关重要.
- 之前的研究表明,前额-条-甲状腺-皮层电路与运动控制有关.
- 在强迫症障碍 (OCD) 中,潜在的受损运动反应抑制的特定大脑区域仍然不清楚.
研究的目的:
- 在没有药物治疗的强迫症患者中,确定与受损运动反应抑制相关的关键大脑区域.
- 研究休息状态大脑活动与强迫症中运动反应抑制能力之间的关系.
- 为了比较强迫症患者和健康对照组 (HC) 的这些关联.
主要方法:
- 使用静止状态功能磁共振成像 (fMRI) 计算低频波动的分数振幅 (fALFF).
- 使用停止信号任务评估了运动反应抑制.
- 包括41名没有药物的强迫症患者和49名HC参与者.
主要成果:
- 在背后环状皮质 (PCC) 中发现了与运动反应抑制相关的fALFF的显著差异.
- 在强迫症患者中,背部PCC中fALFF增加与运动反应抑制受损正相关.
- 在HC参与者中,背部PCC中的fALFF与运动反应抑制有负相关性.
结论:
- 背部PCC中静止状态振荡的幅度是强迫症中受损运动反应抑制的关键神经机制.
- 背部PCC在运动反应抑制中的作用需要在强迫症中大规模大脑网络的背景下进一步研究.
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