产前接触酸盐与出生体重之间的关联:一项元分析研究
Shihao Jin1, Shanshan Cui2, Jinghan Xu1
1Department of Maternal, Child and Adolescent Health, School of Public Health, Tianjin Medical University, No. 22 Qixiangtai Road, Tianjin 300070, PR China.
Ecotoxicology and environmental safety
|July 2, 2023
概括
产前接触某些酸盐,如单-n-丁酸盐和单-甲基酸盐,与婴儿出生体重降低有关. 这种关联似乎是针对女性的mono-n-butyl甲酸盐.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 儿科研究 儿科研究
背景情况:
- 酸盐是常见的环境污染物.
- 以前的研究表明,酸盐暴露与出生体重之间存在联系.
- 缺乏对各种甲酸代谢物及其对出生体重的影响的全面分析.
研究的目的:
- 进行一项元分析,评估产前甲酸盐暴露与婴儿出生体重之间的关系.
- 探索特定的甲酸代谢物与出生体重的关联.
- 研究甲酸盐暴露对出生体重的潜在性别特异性影响.
主要方法:
- 系统的文献搜索测量甲酸盐暴露和出生体重的研究.
- 基于异质性的固定效应或随机效应模型的元分析.
- 提取和分析回归系数 (β) 和95%置信区间 (CI).
主要成果:
- 产前暴露于单一-n-丁甲酸盐显示与出生体重有负面关联 (总 β = -11.34 g).
- 产前暴露于单甲基甲酸盐也显示出与出生体重的负相关性 (总 β = -8.78 g).
- 暴露于mono-n-butyl甲酸盐与女性婴儿出生体重较低 (β = -10.74 g) 有显著的关联.
结论:
- 暴露于甲酸盐,特别是单-n-甲酸盐和单-甲基甲酸盐,可能是婴儿出生体重降低的危险因素.
- 单一-n-丁甲酸盐暴露与出生体重之间的关联似乎是性别特异性的,对女性的影响更为显著.
- 需要进一步的研究来了解甲酸盐对健康的危害,并为预防策略提供信息.
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