相关实验视频

Updated: Jul 24, 2025

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

用硫酸在两分钟后进行的重复治疗苏格玛德克斯逆转:一个随机,双盲,受控试验

Paulo A Germano-Filho¹, Ismar L Cavalcanti², Angelo J Q R Micuci³

¹Department of Surgery, Anesthesiology, Surgical Sciences Postgraduate Program, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Department of General and Specialized Surgery, Anesthesiology, Universidade Federal Fluminense, Niterói, Brazil.

Journal of clinical anesthesia

|July 2, 2023

概括

在Sugammadex逆转神经肌肉阻塞后,硫酸的使用显著增加了复发的风险. 在深度和中度阻塞场景中观察到这种效应,需要额外的sugammadex才能恢复.

科学领域:

麻醉学麻醉学
药理学药理学是指药理学的学科.

背景情况:

苏加马德克斯是一种神经肌肉阻断剂的逆转剂,如罗库.
硫酸盐在苏格玛德克斯逆转后可能导致复发的可能性尚未得到充分证实.

研究的目的:

为了测试一种假设,即在苏格玛德克斯逆转后施用硫酸会导致复发的假设.
为了评估在接受硫酸盐或安慰剂后复发的发病率,在患者中用sugammadex进行逆转.

主要方法:

这是一项前性,随机,双盲,受控试验,涉及60名接受选择性耳鼻喉手术的患者.
患者在不同深度的阻塞中接受了rocuronium和神经肌肉阻塞逆转与sugammadex.
康复后,患者随机分配接受硫酸或安慰剂,通过加速肌图监测神经肌肉功能.

主要成果:

在深度阻塞系列中,接受硫酸的患者中有64%的患者经历了复发,与安慰剂7%相比 (p=0.002).
在中度阻塞系列中,接受硫酸的73%的患者出现了复发,而安慰剂患者为0% (p<0.001).
在硫酸组中,复发率明显高于硫酸组,绝对差异为57%和73%.

结论:

单剂量硫酸的使用会导致在sugammadex逆转后的复发,从而扭转由罗库引起的神经肌肉阻塞.
这些发现凸显了在使用硫酸后使用sugammadex时,复发的显著风险.
需要额外的sugammadex来逆转长期的神经肌肉阻塞在受影响的患者.

关键词:

硫酸硫酸是什么硫酸是什么神经肌肉阻塞的阻塞神经肌肉阻断剂是一种神经肌肉阻断剂.在手术后的残留治疗.罗库的含量是多少罗库的含量是多少这就是Sugammadex.

更多相关视频

Biodegradable Magnesium Stent Treatment of Saccular Aneurysms in a Rat Model - Introduction of the Surgical Technique

Biodegradable Magnesium Stent Treatment of Saccular Aneurysms in a Rat Model - Introduction of the Surgical Technique

Published on: October 1, 2017

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

相关概念视频

Skeletal Muscle Relaxants: Adverse Effects

Skeletal Muscle Relaxants: Adverse Effects

Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...

Depolarizing Blockers: Pharmocokinetics

Depolarizing Blockers: Pharmocokinetics

Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...