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在COVID-19后的儿童中,呼出的呼吸凝结物和呼吸后续
Einat Fireman Klein1,2, Karin Yaacoby-Bianu2,3, Ido Orlin4
1Pulmonology division, Carmel Medical Center, Haifa, Israel.
概括
大多数儿童经历了轻度的COVID-19并没有长期呼吸问题而恢复. 在儿童中,COVID-19后的评估表明,在没有持续症状的儿童中,没有显著的肺部继发症.
科学领域:
- 儿科肺病学 儿科肺病学
- 传染性疾病 传染性疾病
- 呼吸系统医学 呼吸系统医学
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 导致急性呼吸系统疾病,显著比例的成年人出现持续症状.
- 在SARS-CoV-2感染后儿童的长期呼吸系统影响的数据有限.
- 呼出的呼吸凝聚物 (EBC) 提供了一种非侵入性方法来评估气道炎症.
研究的目的:
- 为了评估COVID-19后儿童的呼气凝结物 (EBC) 参数.
- 评估COVID-19后儿科患者的呼吸,精神和身体能力.
- 在SARS-CoV-2感染后的儿童中调查潜在的肺部继发症.
主要方法:
- 一项观察性研究涉及5至18岁的儿童,他们已确认感染了SARS-CoV-2.
- 评估包括螺旋测量,6分钟步行测试 (6MWT),EBC分析 (pH,中白素-6),以及关于病史,心理健康 (DASS-21) 和身体活动的问卷.
- 根据世界卫生组织 (WHO) 的标准对COVID-19的严重程度进行了分类.
主要成果:
- 分析了58名儿童,分为无症状 (n=14),轻度 (n=37) 和中度 (n=7) 的疾病.
- 与轻度和中度组相比,无症状儿童年轻,报告抑郁症,焦虑和压力评分 (DASS-21) 较低.
- 在EBC标志物,6MWT,螺旋计,BMI百分位数或活动得分方面没有观察到跨组的显著差异.
结论:
- 在大多数年轻,健康的儿童中,COVID-19呈现为无症状至轻度疾病,情绪症状逐渐减少.
- 没有长期呼吸道症状的儿童根据EBC,螺旋测量,6MWT和活动评估没有显著的肺部后果.
- 需要对更大群体进行进一步的研究,以了解SARS-CoV-2的长期儿科后果,并确定肺部监测的必要性.
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