埃莫丁破坏了Notch1/Nrf2/GPX4抗氧化系统,并促进细胞铁亡

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Updated: Jul 24, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

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Miao Xing1, Xiaoyu Ma1, Xi Wang1

  • 1School of Medicine, Yichun University, Yichun, China.

Journal of applied toxicology : JAT
|July 2, 2023
PubMed
概括

埃莫丁通过诱导铁,一个涉及铁积累和氧化应激的过程,引起毒性. 这通过抑制Notch1/Nrf2/glutathione过氧化酶4通路而发生,突出了emodin诱导的毒性的一种新机制.

关键词:
在GPX4中使用GPX4.标记1 标记1 标记Nrf2 没有任何问题.埃莫丁是一种催产素.铁性化 (ferroptosis) 是一种毒性 毒性 毒性

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