鱼类对SARS-CoV-2的看法:化对丹尼奥河的毒性
Beatriz Sousa1, Inês Domingues1, Bruno Nunes1
1Centro de Estudos do Ambiente e do Mar (CESAM), Universidade De Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; Departamento De Biologia, Universidade De Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.
Environmental toxicology and pharmacology
|July 2, 2023
概括
消毒剂甲 (BAC) 显著影响斑马鱼,导致行为变化和代谢障碍. 增加BAC使用对水生生态系统和野生动物构成威胁.
科学领域:
- 环境毒理学环境毒理学
- 水生物质毒理学研究
- 生物化学 生物化学
背景情况:
- SARS-CoV-2 流行病增加了消毒剂的使用,引发了环境问题.
- 废水中的甲化物 (BAC) 含量可能会上升,威胁水生生物.
研究的目的:
- 调查急性化 (BAC) 暴露对斑马鱼的不良影响.
- 描述暴露于BAC的斑马鱼的行为和代谢变化.
主要方法:
- 斑马鱼对不同度的BAC的急性暴露.
- 观察行为变化 (游泳活动,tighmotaxis).
- 酶活动的测量 (CYP1A1,催化酶,CY1A2,GSTs,GPx,ACHE).
主要成果:
- 观察到游泳活动增加,tighmotaxis和不规则的运动.
- 增加CYP1A1和催化酶活动;抑制CY1A2,GST和GPx活动.
- 已注意到乙胆酶 (AChE) 活性增加.
结论:
- 暴露于BAC会对斑马鱼产生显著的胚胎,行为和代谢不良影响.
- 这些发现强调了与增加BAC使用和释放相关的环境风险.
- 斑马鱼作为一种模型生物来了解BAC的生态毒理影响.
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