生物材料辅助巨细胞疗法用于再生医学
Samuel Sung1, Lindsay A Steele1, Gregory E Risser1
1School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA.
Advanced drug delivery reviews
|July 2, 2023
概括
生物材料可以控制巨细胞的表型,并改善再生医学的保留. 这种方法解决了当前巨细胞治疗难治损伤的挑战.
科学领域:
- 再生医学是一种再生医学.
- 免疫学 免疫学 免疫学
- 生物材料科学 生物材料科学
背景情况:
- 超过关键值的受伤或疾病会损害组织的修复,导致功能丧失.
- 免疫系统,特别是巨细胞,对于组织修复至关重要,表现出不同的功能和表型.
- 目前的巨细胞疗法面临着细胞保留和管理后维持治疗表型的挑战.
研究的目的:
- 探索巨细胞疗法的挑战,特别是细胞保留和表型控制.
- 研究生物材料在克服这些挑战的潜力,以增强组织再生.
- 讨论使用生物材料的下一代再生医学策略的机会.
主要方法:
- 关于巨细胞疗法和生物材料应用的当前文献的综述.
- 分析生物材料如何在现场调节巨细胞的行为.
- 在细胞输送系统中探索免疫调节信号.
主要成果:
- 通过收养转移的巨细胞往往无法维持所需的治疗表型.
- 生物材料提供了一种控制巨细胞表型和改善受伤部位保留的策略.
- 具有免疫调节信号的细胞传递系统对难以治疗的损伤有希望.
结论:
- 生物材料对于通过控制细胞表型和保留来推进巨细胞疗法至关重要.
- 克服目前的局限性将使巨细胞疗法的广泛临床应用成为可能.
- 整合生物材料的下一代策略是实现复杂伤害组织再生的关键.
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