新型pH响应的E-选择蛋白向天然多糖化合物 混合菌对糖尿病病的治疗方法
Chunjing Guo1, Min Cao2, Ningning Diao2
1College of Marine Life Science, Ocean University of China, 5# Yushan 10 Road, Qingdao 266003, PR China.
Nanomedicine : nanotechnology, biology, and medicine
|July 2, 2023
概括
通过向脏炎症和氧化应激,新型混合有效地提供普埃拉林来治疗糖尿病病.
科学领域:
- 生物材料科学 生物材料科学
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 糖尿病病 (DN) 是末期病的主要原因,由包括代谢障碍和炎症在内的复杂因素驱动.
- 目前针对DN的治疗方法在有效向脏炎症途径方面面临挑战.
研究的目的:
- 开发新型混合细胞,用于在糖尿病脏病中向药物输送.
- 研究这些细胞在抑制炎和氧化应激方面的潜力.
主要方法:
- 使用安吉利卡辛尼斯多糖 (ASP) 和阿斯特拉加卢斯多糖 (APS) 装载着普埃拉林 (Pue) 的pH响应混合菌粒的制造.
- 用酸 (SA) 修改小粒细胞,通过E-选择素受体增强对炎症性内皮细胞的向.
- 使用薄膜分散方法来制备.
主要成果:
- 开发出能够对pH反应药物释放的混合 (SHB和SPHB).
- 在炎症的血管内皮细胞上证明了SA-修饰的细胞与E-选择素的特定结合.
- 展示了针对性地将普埃拉林输送到脏炎症部位.
结论:
- 这项研究提出了一个有前途的策略,使用基于天然多糖的混合来治疗糖尿病病.
- 这些微粒有效抑制脏炎症反应和氧化应激,提供一种潜在的治疗方法.
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