多巴胺基D1受体调节了Paba突变小鼠的过度活动
Marisa Alves de Oliveira-Higa1, Paula da Silva Rodrigues1, Ana Claudia Silva Sampaio1
1Psychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology, Paulista University, São Paulo, Brazil.
Behavioural brain research
|July 2, 2023
概括
突变的Bate-palmas (bapa) 老鼠表现出与增加的条状多巴胺D1受体基因表达相关的过度活动,这表明这种受体在它们的运动缺陷中起着关键作用.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 突变的Bate-palmas (bapa) 小鼠表现出运动失调和姿势变化.
- 之前的研究表明,在巴巴小鼠中,由于状氨酸氧酶表达的增加和多巴胺基系统的过活性,导致过活性.
研究的目的:
- 为了调查条状多巴胺基受体在帕帕小鼠中观察到的过活性的参与.
主要方法:
- 用开放场测试来评估自发运动行为.
- 在阿波莫尔芬给药后评估了刻板印象.
- 分析了DR1和DR2对抗剂 (SCH-23,390和硫皮化物) 和状DR1和D2受体基因表达的作用.
主要成果:
- 与野生型 (WT) 小鼠相比,巴巴小鼠在阿波莫尔芬后表现出增加的一般活动和养殖/嗅探行为.
- 在巴巴小鼠中,DR2抗剂阻断了养行为,而DR1抗剂阻断了嗅探行为.
- 在阿波莫芬给药后,状DR1受体基因表达增加,DR2受体基因表达在巴巴小鼠中减少.
结论:
- 帕帕小鼠的过度活跃和特定的行为改变与改变的多巴胺基受体功能有关.
- 增加的条状DR1受体基因表达是促进阿波莫尔芬诱导的增强育儿行为的一个关键因素.
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