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微聚乙烯塑料和[α]烯的暴露会影响内分泌系统,并在Carassius auratus中引起生理压力

Jin A Kim¹, Jun-Hwan Kim², Young-Su Park³

¹Department of Convergence Study on the Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, Republic of Korea.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

|July 2, 2023

概括

微塑料和子烯 (BaP) 暴露会导致金鱼的压力和DNA损伤. 联合暴露会放大这些影响,微塑料是比单独的BaP更重要的压力因素.

科学领域:

环境毒理学环境毒理学
水生物质毒理学研究
生态毒理学生态毒理学

背景情况:

微塑料 (MP) 可以吸附持久有机污染物,如多环芳 (PAHs).
金鱼 (Carassius auratus) 容易受到环境压力因素的影响.
了解污染物的综合影响对于水生生态系统的健康至关重要.

研究的目的:

研究[α]烯 (BaP) 和微塑料 (MP) 对金鱼应激反应和DNA损伤的单独和联合影响.
为了评估BaP和MP暴露之间的协同相互作用.
确定金鱼中BaP和MP的相对诱导压力的潜力.

主要方法:

金鱼暴露于不同度的BaP和/或MP (1.0μm).
通过测量脑下垂体,下丘脑和肝脏的mRNA表达 (CRH,ACTH,CYP1A1,MT) 来评估应激反应.
测量了血皮质醇水平,H2O2度和DNA损伤.

主要成果:

对BaP和MP的暴露单独增加了金鱼的压力标志物和DNA损伤.
与单次暴露相比,联合BaP和MP暴露导致了协同效应,显著增加了压力和DNA损伤.
微塑料被确定为比BaP更强大的压力源,基于下丘脑-垂体-内脏 (HPI) 轴的基因表达.

结论:

BaP和MP都会诱导金鱼的压力和DNA损伤.
BaP和MP的组合表现出协同毒性,导致放大压力和DNA损伤.
微塑料对金鱼的压力风险比BaP更大,凸显了水生生态系统中塑料污染对环境的关注.

关键词:

子[α]二烯是一种二烯.卡拉西乌斯·奥拉图斯 (Carassius auratus) 是一个的动物.环境压力因素环境压力因素微塑料是一种微塑料.微聚乙烯微聚乙烯的使用

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